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In this study, pharmacologic effects of COMT inhibition during sleep deprivation in healthy subjects in dependence of their Val158Met genotype of COMT are studied. Potential effects are identified by measurement of vigilance and cognitive performance as well as EEG measurements during wake and sleep.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tolcapone | Experimental | Tasmar |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tolcapone | Drug | 2 x 100mg Tolcapone compared to placebo (randomized, double-blind, cross-over) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of vigilance during prolonged wakefulness after intake of tolcapone when compared to placebo | Vigilance is measured subjectively (questionnaires and visual analogue scales) and objectively (e.g., psychomotor vigilance task: reaction times and number of lapses; waking EEG: spectral power) at 3-hour intervals during 40 hours prolonged wakefulness in 30 healthy male adults. | Participants will be studied during two weeks |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hans-Peter Landolt, Professor | University of Zurich, Institute of Pharmacology and Toxicology | Study Chair |
| Christian Baumann, MD | University Hospital Zurich, Department of Neurology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Zurich, Institute of Pharmacology and Toxicology | Zurich | Switzerland |
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| ID | Term |
|---|---|
| D000077867 | Tolcapone |
| ID | Term |
|---|---|
| D001577 | Benzophenones |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Placebo | Drug |
|
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D009596 | Nitrophenols |
| D010636 | Phenols |
| D007659 | Ketones |
| D009574 | Nitro Compounds |