This study is designted to know optimal dose of Ramosteron to control for chemotherapy induced nasea and vomoting (CINV)based on its pharmacokinetics, pharmacodynamic study and clinilcal parameters using Rhodes Index.

Nausea and vomiting is a common adverse event during chemotherapy treatment. Even if preventive medicines such as dopamine receptor antagonist, corticosteroid, serotonin receptor antagonist, has been developed and used, there is residual nausea and/or vomiting in a significant percentage of patients treated for cancer. Serotonin receptor antagonist is the most potent antiemetic agent and has been used widely. However, the optimal dose of serotonin antagnosit based on individual symptoms is not defined. Therefore, this study was conducted to design standardization model for optiomal serotonin antagonist concentration using pharmacodynamic study and Rhodes Index as a suggogate marker for CINV.

Inclusion Criteria:

• Patients who recevied moderate emetogenic chemotherapy
• Age between 18-75
• ECOG PS 0-2
• Adequate organ fuction including bone marrow, liver and kidney

Exclusion Criteria:

• Gastrointestinal obstruction or carcinomatosis peritonei
• CNS metastasis or disability in CNS
• Intractable medical illness
• Pregnancy or inadequate contraception