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| Name | Class |
|---|---|
| Bariatric Clinic, Department of Surgery, Køge Hospital, Denmark | UNKNOWN |
| Copenhagen University Hospital, Hvidovre | OTHER |
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The overall aim is to study the multiple factors determining the variation of weight loss after Roux-en-Y Gastric Bypass (RYGB) and Sleeve surgery.
The specific aims are to evaluate:
a) what explains the large individual differences in weight loss seen after RYGB and Sleeve surgery, b) if it is possible pre-operatively to identify which patients will not obtain beneficial effects of bariatric surgery in relation to weight loss and quality of life and c) if patients in need of improved care can be identified pre- and/or early post-operatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Surgery | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Roux-en-Y gastric bypass surgery or sleeve surgery | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Weight loss | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic profile | Insulin, glucose, C-peptide, GIP, glucagon, TSH, thyroid hormones, vitamin D and blood lipids | 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively |
| Physical activity |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Science, NEXS | Frederiksberg | 1958 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32016415 | Derived | Nielsen MS, Ritz C, Wewer Albrechtsen NJ, Holst JJ, le Roux CW, Sjodin A. Oxyntomodulin and Glicentin May Predict the Effect of Bariatric Surgery on Food Preferences and Weight Loss. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgaa061. doi: 10.1210/clinem/dgaa061. | |
| 31556242 | Derived | Nielsen MS, Andersen INSK, Lange B, Ritz C, le Roux CW, Schmidt JB, Sjodin A, Bredie WLP. Bariatric Surgery Leads to Short-Term Effects on Sweet Taste Sensitivity and Hedonic Evaluation of Fatty Food Stimuli. Obesity (Silver Spring). 2019 Nov;27(11):1796-1804. doi: 10.1002/oby.22589. Epub 2019 Sep 26. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively |
| Appetite sensation | Following a test meal with the use of visual analogue scales (VAS) | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively |
| Taste preferences and taste perception | Sensory tests, picture displays (all visits) and an ad libitum test meals (3 months preoperatively and 6 months postoperatively) are used to investigate changes in taste and food preferences (liking and wanting) and taste perception | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively |
| Mental health | 3 month preoperatively, 6 month postoperatively and 18 month postoperatively |
| Social resources | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively |
| Gut microbiota | 1 week preoperatively, 6 month postoperatively |
| Appetite-regulating hormones | GLP-1, PYY, leptin, ghrelin, OXM, CCK, glicentin | 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively |
| Bile acids and fibroblast growth factors | 3 month preoperatively, 1 week preoperatively, 6 month postoperatively and 18 month postoperatively |
| Genetics | 3 month preoperatively |
| Body composition | By DXA scans | 3 month preoperatively, 1 week preoperatively, 6 weeks postoperatively, 6 month postoperatively and 18 month postoperatively |
| Cortisol | Measured in hair | 3 month preoperatively and 18 month postoperatively |
| Neural activity in reward-processing brain centers | By functional magnetic resonance imaging (fmri) | preoperatively and 6 month postoperatively |
| Rewarding value of food | Behavioral test | preoperatively and 6 month postoperatively |
| 30722827 | Derived | Taekker L, Lunn S. The effect of mental health on weight loss after bariatric surgery. Dan Med J. 2019 Feb;66(2):A5532. |
| 30421858 | Derived | Sondergaard Nielsen M, Rasmussen S, Just Christensen B, Ritz C, le Roux CW, Berg Schmidt J, Sjodin A. Bariatric Surgery Does Not Affect Food Preferences, but Individual Changes in Food Preferences May Predict Weight Loss. Obesity (Silver Spring). 2018 Dec;26(12):1879-1887. doi: 10.1002/oby.22272. Epub 2018 Nov 13. |
| 30023446 | Derived | Christensen BJ, Schmidt JB, Nielsen MS, Taekker L, Holm L, Lunn S, Bredie WLP, Ritz C, Holst JJ, Hansen T, Hilbert A, le Roux CW, Hulme OJ, Siebner H, Morville T, Naver L, Floyd AK, Sjodin A. Patient profiling for success after weight loss surgery (GO Bypass study): An interdisciplinary study protocol. Contemp Clin Trials Commun. 2018 Feb 17;10:121-130. doi: 10.1016/j.conctc.2018.02.002. eCollection 2018 Jun. |
| 28411313 | Derived | Nielsen MS, Christensen BJ, Ritz C, Rasmussen S, Hansen TT, Bredie WLP, le Roux CW, Sjodin A, Schmidt JB. Roux-En-Y Gastric Bypass and Sleeve Gastrectomy Does Not Affect Food Preferences When Assessed by an Ad libitum Buffet Meal. Obes Surg. 2017 Oct;27(10):2599-2605. doi: 10.1007/s11695-017-2678-6. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |