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| Name | Class |
|---|---|
| Tongji Hospital | OTHER |
| Huashan Hospital | OTHER |
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bilateral temporal and propofol | Experimental | During the MECT treatment, electrodes are placed at bilateral temporal, with propofol 2mg/kg to Induce anesthesia. |
|
| Bilateral temporal and etomidate | Experimental | During the MECT treatment, electrodes are placed at bilateral temporal, with etomidate 0.3mg/kg to Induce anesthesia. |
|
| The right temporal and propofol | Experimental | During the MECT treatment, electrodes are placed at the right temporal, with propofol 2mg/kg to Induce anesthesia. |
|
| The right temporal and etomidate | Experimental | During the MECT treatment, electrodes are placed at the right temporal, with etomidate 0.3mg/kg to Induce anesthesia. |
|
| Bilateral frontal and propofol | Experimental | During the MECT treatment, electrodes are placed at bilateral frontal, with propofol 2mg/kg to Induce anesthesia. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Etomidate | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Hamilton Depression Scale(HAMD) Scores | Change from Baseline in Hamilton Depression Scale scores at 7d, 14d, 21d, 28d, 35d, 42d and 180d after the last MECT session | |
| Change in Wechsler Memory Scale (WMS) Scores as a Measure of Safety | Change from Baseline in Wechsler Memory Scale (WMS) Scores at 42d and 180d after the last MECT session |
| Measure | Description | Time Frame |
|---|---|---|
| Young Manic Rating Scale(MMSE) as a Measure for Evaluation of Mania State | 42d and 180d after the last MECT session | |
| Resting-state/Task-state functional magnetic resonance imaging (fMRI) | Change form Baseline in Resting-state/Task-state fMRI Imging Results at 42d and 180d after the last MECT session |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Mental Health Center | Shanghai | China |
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| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D005045 | Etomidate |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
| Bilateral frontal and etomidate | Experimental | During the MECT treatment, electrodes are placed at bilateral frontal, with etomidate 0.3mg/kg to Induce anesthesia. |
|
| Standard-therapy Group | Active Comparator | During the MECT treatment, electrodes are placed at bilateral temporal, with etomidate 0.3mg/kg to Induce anesthesia. |
|
| Propofol | Drug |
|
| Bilateral temporal MECT | Device |
|
| The right temporal MECT | Device |
|
| Bilateral frontal MECT | Device |
|
| Change in Hamilton Anxiety Scale(HAMA) Scores | Change from Baseline in Hamilton Anxiety Scale Scores at 7d, 14d, 21d, 28d, 35d, 42d and 180d after the last MECT session |
| Change in Clinical Global Impression-severity of illness(CGI-SI) Scores as a Measure of Efficacy | Change from Baseline in CGI-SI Scores at 7d, 14d, 21d, 28d, 35d, 42d and 180d after the last MECT session |
| Change in Wisconsin Card Sorting Test(WCST) Scores as a Measure of Safety | Change from Baseline in Wisconsin Card Sorting Test(WCST) Scores at 42d and 180d after the last MECT session |
| Change in P300/P50 Event-Related Potentials(ERP) | Change from Baseline in P300/P50 Event-Related Potentials(ERP) at 42d and 180d after after the last MECT session |
| D010636 |
| Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |