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| Name | Class |
|---|---|
| Tianjin TongRenTang Group Co., Ltd. | UNKNOWN |
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-Evaluate the efficacy and safety of Shenyankangfu Tablets to control the proteinuria of patients with primary glomerulonephritis compare with Losartan potassium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Shenyankangfu tablets and Losartan potassium 100mg | Experimental |
| |
| Shenyankangfu tablets and Losartan potassium 50mg | Experimental |
| |
| Losartan potassium 50mg | Experimental |
| |
| Shenyankangfu tablets | Experimental |
| |
| Losartan potassium 100mg | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Shenyankangfu tablets | Drug | Shenyankangfu tablets 2.4g, po, 3/day and Losartan potassium placebo 2 tab, po, 1/day,all drugs and placebo are taken for 48 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes of 24 hours proteinuria after the treatment | 0,4,8,12,24,36,48 weeks after the enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| changes of serum creatinine after treatment | 0,4,8,12,24,36,48 weeks after the enrollment | |
| changes of eGFR after the treatment | 0,4,8,12,24,36,48 weeks after the enrollment | |
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Inclusion
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| jie wu, doctor | Contact | +86-010-66937763 | wujie301@126.com | |
| jia kou, doctor | Contact | chinakoujia@163.com |
| Name | Affiliation | Role |
|---|---|---|
| xiangmei chen, Doctor | State Key Laboratory of Kidney Diseases,Chinese PLA General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Clinical Research Center for Kidney Disease, State Key Laboratory of Kidney Disease, Department of Nephrology, Chinese PLA General Hospital | Recruiting | Beijing | Beijing Municipality | 100853 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33589406 | Derived | Wu J, Duan SW, Yang HT, Deng YY, Li W, He YN, Ni ZH, Zhan YL, Lin S, Guo ZY, Zhu J, Fang JA, Liu XS, Wang LH, Wang R, Wang NS, Cheng XH, He LQ, Luo P, Sun SR, Sun JF, Yin AP, Jiang GR, Chen HY, Liu WH, Lin HL, Liang M, Ma L, Chen M, Song LQ, Chen J, Zhu Q, Xing CY, Li Y, Gao JN, Li RS, Li Y, Zhang H, Lu Y, Zhou QL, Fu JZ, He Q, Cai GY, Chen XM. Efficacy and safety of Shenyankangfu Tablet, a Chinese patent medicine, for primary glomerulonephritis: A multicenter randomized controlled trial. J Integr Med. 2021 Mar;19(2):111-119. doi: 10.1016/j.joim.2021.01.009. Epub 2021 Jan 30. | |
| 25480673 |
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| Losartan potassium 50mg | Drug | Shenyankangfu tablets placebo 5 tab, po, 3/day and losartan potassium 50mg,po, 1/day and losartan potassium placebo1 tab,po, 1/day, all drugs and placebo are taken for 48 weeks. |
|
| Shenyankangfu tablets and Losartan potassium 50mg | Drug | Shenyankangfu tablets 2.4g, po, 3/day and losartan potassium 50mg,po, 1/day and losartan potassium placebo1 tab, po, 1/day, all drugs and placebo are taken for 48 weeks. |
|
| Shenyankangfu tablets and Losartan potassium 100mg | Drug | Shenyankangfu tablets 2.4g, po, 3/day and losartan potassium 50mg×2,po, 1/day, all drugs and placebo are taken for 48 weeks. |
|
| Losartan potassium 100mg | Drug | Shenyankangfu tablets placebo 5 tab, po, 3/day and losartan potassium 50mg×2,po, 1/day, all drugs and placebo are taken for 48 weeks. |
|
| changes of Traditional Chinese Medicine syndrome scores after the treatment |
| 0,4,8,12,24,36,48 weeks after the enrollment |
|
| Beijing Friendship,Capital Medical University | Recruiting | Beijing | Beijing Municipality | China |
| Guang'anmen Hospital, China Academy of Chinese Medical Sciences | Recruiting | Beijing | Beijing Municipality | China |
| XIyuan Hospital CACMS | Not yet recruiting | Beijing | Beijing Municipality | China |
| Daping Hospital,Research Institute of Surgery Third Military Medical University | Recruiting | Chongqing | Chongqing Municipality | China |
| Fuzhou General Hospital Nanjing Military Command | Recruiting | Fuzhou | Fujian | China |
| 174th hospital of the People's Liberation Army | Recruiting | Xiamen | Fujian | China |
| Guangdong Province Hospital of Chinese Medical | Recruiting | Guangzhou | Guangdong | China |
| Guangzhou First People's Hospital | Recruiting | Guangzhou | Guangdong | China |
| Beidaihe Sanatorium of Beijing Military Mrca | Recruiting | Qinhuangdao | Hebei | China |
| The Third Hospital of hebei Medical University | Recruiting | Shijiazhuang | Hebei | China |
| Heilongjiang University of Chinese Medicine | Recruiting | Harbin | Heilongjiang | China |
| Henan Provincial People'S Hospital | Recruiting | Zhengzhou | Henan | China |
| The Second Xiangya Hospital of Central South University | Not yet recruiting | Changsha | Hunan | China |
| The Third Xiangya Hospital of Central South University | Recruiting | Changsha | Hunan | China |
| Xiangya Hospital Central South University | Recruiting | Changsha | Hunan | China |
| Jiangsu Province Hospital | Recruiting | Nanjing | Jiangsu | China |
| Jiangxi Provincil People'S Hospital | Recruiting | Nanchang | Jiangxi | China |
| The Second Hospital of Jilin University | Recruiting | Changchun | Jilin | China |
| First Affilated Hospital of Dalian Medical University | Recruiting | Dalian | Liaoning | China |
| Shaanxi Traditional Chinese Medicine Hospital | Recruiting | Xi'an | Shaanxi | China |
| Tangdu Hospital | Recruiting | Xi'an | Shaanxi | China |
| The First Affiliated Hospital of Xi'An Jiaotong University | Recruiting | Xi'an | Shaanxi | China |
| Xijing Hospital | Recruiting | Xi'an | Shaanxi | China |
| Shandong Province Hospital | Recruiting | Jinan | Shandong | China |
| Teaching Hospital of Shandong University of Traditional Chinese Medicine | Recruiting | Jinan | Shandong | China |
| Changhai Hospital of Shanghai | Recruiting | Shanghai | Shanghai Municipality | China |
| LONGHUA Hospital Shanghai University of TCM | Recruiting | Shanghai | Shanghai Municipality | China |
| Shanghai Jiao Tong University School of Medicine | Recruiting | Shanghai | Shanghai Municipality | China |
| Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University | Recruiting | Shanghai | Shanghai Municipality | China |
| Shugaung Hospital | Recruiting | Shanghai | Shanghai Municipality | China |
| Xin Hua Hospital Affiated to Shanghai Jiao Tong University School of Medicine | Recruiting | Shanghai | Shanghai Municipality | China |
| First Hospital of Shanxi Medical University | Recruiting | Taiyuan | Shanxi | China |
| Second Hospital of Shanxi Medical University | Recruiting | Taiyuan | Shanxi | China |
| Shanxi Hospital of Integrated Traditional and Westem Medicine | Recruiting | Taiyuan | Shanxi | China |
| Shanxi Provincial People's Hospital | Recruiting | Taiyuan | Shanxi | China |
| General Hospital of Chengdu Military Region of PLA | Recruiting | Chengdu | Sichuan | China |
| Teaching Hospital of Chengdu University of T.C.M | Recruiting | Chengdu | Sichuan | China |
| First Teaching Hospital of Tianjin University of TCM | Recruiting | Tianjin | Tianjin Municipality | China |
| Tianjin Medical University General Hospital | Recruiting | Tianjin | Tianjin Municipality | China |
| Hangzhou Hospital of Traditional Chinese Medicine | Recruiting | Hangzhou | Zhejiang | China |
| Tongde Hospital of Zhejiang Province | Recruiting | Hangzhou | Zhejiang | China |
| Zhejiang Provncial People'S Hospital | Recruiting | Hangzhou | Zhejiang | China |
| Derived |
| Kou J, Wu J, Yang HT, He YN, Fang JA, Deng YY, Xie YS, Nie LF, Lin HL, Cai GY, Chen XM. Efficacy and safety of Shenyankangfu tablets for primary glomerulonephritis: study protocol for a randomized controlled trial. Trials. 2014 Dec 5;15:479. doi: 10.1186/1745-6215-15-479. |
| ID | Term |
|---|---|
| D005921 | Glomerulonephritis |
| D011507 | Proteinuria |
| ID | Term |
|---|---|
| D009393 | Nephritis |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D014555 | Urination Disorders |
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D019808 | Losartan |
| ID | Term |
|---|---|
| D001713 | Biphenyl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D013777 | Tetrazoles |
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