Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3

Multi-Center,Double-Blind,Randomized,Controlled Clinical Trial of Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3

The purpose of this study is to determine whether fosinopril and losartan are effective in the treatment of patients with Chronic Kidney Disease(CKD) stage 3.

Inclusion Criteria:

• Patients aged 18-75 years old
• Roll out secondary renal diseases
• Do not use steroids and immunosuppresive drugs
• ACEI/ARB treated patients should have 7-14 days wash out period，SiDBP< 110mmHg
• Willing and able to comprehend and give written informed consent
• Willing to follow-up regularly

Exclusion Criteria:

• Use steroids and immunosuppresive drugs
• Secondary renal diseases
• Acute cardio-cerebral diseases within 6 months
• Post renal transplantation
• Pregnant/Nursing women
• History of hypersensitivity to ACEI/ARB
• Refuse to join clinical trial