EVLP to Evaluate the Eligibility for Transplantation of DCD-Lungs

Extracorporeal Lung Perfusion and Ventilation to Evaluate the Eligibility for Transplantation of Lungs Retrieved From Donors After Cardio-circulatory Death (DCD)

The procurement of organs from donors after cardiocirculatory death (DCD) is an accepted strategy to increase organ supply.

Aim of the investigation: to compare the clinical outcome after transplantation of subjects receiving lungs procured from donors after cardiocirculatory death reconditioned and assessed by EVLP, with that of subjects receiving lungs procured from brain death donors.

Lung donors:

• subjects with brain death according to neurological or cardiocirculatory criteria
• age below 65 yrs
• absence of massive lung contusion, aspiration, pneumonia, sepsis
• absence of infection, malignancy

Recipients:

• subjects to undergo single or bilateral lung transplantation
• informed consent to participate in the study