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| ID | Type | Description | Link |
|---|---|---|---|
| 1-10-72-14-14 | Other Identifier | Local ethical committe for medical science |
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The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypoxia | Experimental | Inhaling hypoxic gas mixture to induce hypoxemia during recordings of diameter changes of retinal vessels. Recording are performed during hypoxia alone and in combination with the associated interventions over two examination days |
|
| Normoxia | Experimental | Breathing atmospheric air during recordings of diameter changes of retinal vessels. Recording are performed during normoxia alone and in combination with the associated interventions over two examination days |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| COX-inhibitor | Drug | Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated |
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| Measure | Description | Time Frame |
|---|---|---|
| Diameter changes of retinal vessels | Comparing the differences of diameter changes occuring during each of interventions | Examination day 1 and 2 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Line Pedersen, MD | Aarhus University Hospital | Principal Investigator |
| Musa Kaya, stud.med | Aarhus University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophtalmology, Aarhus University Hospital | Aarhus | 8000 | Denmark |
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| ID | Term |
|---|---|
| D016861 | Cyclooxygenase Inhibitors |
| D005996 | Nitroglycerin |
| ID | Term |
|---|---|
| D004791 | Enzyme Inhibitors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Nitroglycerin | Drug | Oral administration of tablet nitroglycerin 0,5mg 5 minutes before recordings of diameter changes of retinal vessels are initiated |
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| COX-inhibitor + Nitroglycerin | Drug | Combination of COX-inhibitor and nitroglycerin interventions. |
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| D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| D018712 | Analgesics, Non-Narcotic |
| D000700 | Analgesics |
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D000893 | Anti-Inflammatory Agents |
| D045506 | Therapeutic Uses |
| D018501 | Antirheumatic Agents |
| D009574 | Nitro Compounds |
| D009930 | Organic Chemicals |