The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

The Underlying Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Inclusion Criteria:

• Age between >19 and <61 years
• No known systemic or ocular diseases

Exclusion Criteria:

• Cardio-vascular disease
• Lung disease
• Epilepsy
• Previous ocular disease
• Previous treatment with medications influencing the intraocular pressure or the metabolism of nitric oxide or prostaglandins
• Daily intake of medicine except contraceptive pills
• Pregnancy or breastfeeding
• Known allergy against any of the drugs used in the interventions