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The aim of the study is to investigate how the retina adapts to different metabolic challenges, e.g. chronic systemic hypoxia, hyperglycemia, special training conditions or diets as well as transient changes in the content of oxygen and glucose in the blood.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy | Experimental | Healthy study participanats |
|
| Diabetes | Experimental | Patients with diabetes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hyperoxia | Other |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Retinal vessel diameters during hyperoxia | Measurement of retinal vessel diameters before, during and after hyperoxic stimulation. | Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia |
| Retinal perfusion velocities during hyperoxia | Measurement of retinal perfusion velocities before, during and after hyperoxic stimulation. | Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia |
| Retinal oximetry during hyperoxia | Measurement of retinal oximetry status before, during and after hyperoxic stimulation. | Before hyperoxia, after 15 minutes of hyperoxia, 30 minutes after ending hyperoxia |
| Retinal vessel diameters during hyperglycemia | Measurement of retinal vessel diameters before, during and after hyperglycemic stimulation. | Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load |
| Retinal perfusion during hyperglycemia | Measurement of retinal perfusion velocities before, during and after hyperglycemic stimulation. | Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load |
| Retinal oximetry during hyperglycemia | Measurement of retinal oximetry status before, during and after hyperglycemic stimulation. | Before glucose ingestion, every 30 minutes for 3 hours following oral glucose load |
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Healthy individuals
Inclusion Criteria:
Exclusion Criteria:
Patients with diabetes
Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Oliver Klefter, MD | Contact | +45 38 63 48 18 |
| Name | Affiliation | Role |
|---|---|---|
| Oliver Klefter, MD | Glostrup UH | Principal Investigator |
| Michael Larsen, Professor, DMSci | Glostrup UH | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology, Glostrup University Hospital | Recruiting | Glostrup Municipality | 2600 | Denmark |
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| ID | Term |
|---|---|
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
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| Glucose |
| Other |
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