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| Name | Class |
|---|---|
| Beth Israel Deaconess Medical Center | OTHER |
| Brigham and Women's Hospital | OTHER |
| University of Illinois at Urbana-Champaign | OTHER |
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The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
The purpose is to study the effect of infant nutrition on brain development, as measured using Magnetic Resonance (MR) techniques. The investigators will collect detailed information about the diet of each of the infants, and seek to correlate this information with multiple MR measurements, including structural imaging, diffusion imaging, and functional connectivity. The MR scans will be performed at birth and 3 months of age. Dietary information collected will include detailed food diaries describing the feeding habits of the infants, and food frequency questionnaires to characterize the diet of the mother.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infant Group 1 | This group consist of healthy, full-term babies whose mothers have no known medical conditions or complications during pregnancy. |
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| Measure | Description | Time Frame |
|---|---|---|
| Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function | Infants receive an MRI at 3 months of age | |
| Magnetic Resonance Imaging to measure of brain metabolites, brain structures and brain function | Infants receive an MRI scan at less than 2 weeks of age |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional analysis of mothers diet using a food frequency questionnaire | Mothers fill out questionnaire at three months after enrollment into the study |
| Measure | Description | Time Frame |
|---|---|---|
| Mullen Early scales of Learning (MSEL) test | This test is conducted with the infants at 3 months of age prior to the month MRI scan. |
Inclusion Criteria:
Exclusion Criteria:
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The participants are recruited from two major hospitals at the bedside soon after normal delivery.
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| Name | Affiliation | Role |
|---|---|---|
| P Ellen Grant, MD | Boston Children's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Waltham Imaging Center: Boston Childrens Hospital | Waltham | Massachusetts | 02453 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32442637 | Derived | Zollei L, Iglesias JE, Ou Y, Grant PE, Fischl B. Infant FreeSurfer: An automated segmentation and surface extraction pipeline for T1-weighted neuroimaging data of infants 0-2 years. Neuroimage. 2020 Sep;218:116946. doi: 10.1016/j.neuroimage.2020.116946. Epub 2020 May 20. | |
| 30013919 | Derived | Karmacharya S, Gagoski B, Ning L, Vyas R, Cheng HH, Soul J, Newberger JW, Shenton ME, Rathi Y, Grant PE. Advanced diffusion imaging for assessing normal white matter development in neonates and characterizing aberrant development in congenital heart disease. Neuroimage Clin. 2018 May 1;19:360-373. doi: 10.1016/j.nicl.2018.04.032. eCollection 2018. |
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| 29425270 | Derived | Ferradal SL, Gagoski B, Jaimes C, Yi F, Carruthers C, Vu C, Litt JS, Larsen R, Sutton B, Grant PE, Zollei L. System-Specific Patterns of Thalamocortical Connectivity in Early Brain Development as Revealed by Structural and Functional MRI. Cereb Cortex. 2019 Mar 1;29(3):1218-1229. doi: 10.1093/cercor/bhy028. |