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| Name | Class |
|---|---|
| University of Delaware | OTHER |
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The purpose of this study is to see how full-term and pre-term infants' brains relate to their movement and development throughout the first two years of life. All infants who participate in this study will have a magnetic resonance image (MRI) of the brain prior to discharge from the hospital. Infants will then have follow-up appointments every 3-6 months at home or at the Infant Motor Behavior Laboratory at the University of Delaware. The follow-up sessions will test how infants change their movements to respond to interesting objects or sounds in their environment. It is hoped that the results of this study will assist clinicians in developing better testing and treatment methods for those infants at risk for developmental problems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre-Term | Infants born pre-term with birthweight less than 1KG | ||
| Full-Term Infants | Well infants who are born full-term |
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| Measure | Description | Time Frame |
|---|---|---|
| To compare the learning and coordination impairments of extremely low birth weight infants with full term infants at 3 and 6 months of age | To compare the learning and coordination impairments of extremely low birth weight infants with full term infants at 3 and 6 months of age. This is accomplished through a series of play activities. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| To relate the learning and coordination impairments of extremely low birth weight infants at 3 and 6 months of age to their CNS impairments at term age. | To relate the learning and coordination impairments of extremely low birth weight infants at 3 and 6 months of age to their CNS impairments at term age. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the ability of data from learning and coordination impairments and brain MRI / MRS (magnetic resonance spectroscopy) to predict results from common clinical assessments from 3-24 months. | To determine the ability of data from learning and coordination impairments and brain MRI / MRS (magnetic resonance spectroscopy) to predict results from common clinical assessments from 3-24 months. MRI / MRS (magnetic resonance spectroscopy) of the brain was performed as close to term equivalent age as possible. |
Inclusion Criteria:
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Pre-term or full-term infants who are admitted to the Neonatal Intensive Care Unit (NICU) at Christiana Hospital.
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| Name | Affiliation | Role |
|---|---|---|
| David A. Paul, MD | Christiana Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Delaware: Infant Motor Beahvior Lab | Newark | Delaware | 19717 | United States | ||
| Christiana Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22207464 | Derived | Gadin E, Lobo M, Paul DA, Sem K, Steiner KV, Mackley A, Anzilotti K, Galloway C. Volumetric MRI and MRS and early motor development of infants born preterm. Pediatr Phys Ther. 2012 Spring;24(1):38-44. doi: 10.1097/PEP.0b013e31823e069d. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| 24 months. |
| Newark |
| Delaware |
| 19718 |
| United States |
| D000091642 | Urogenital Diseases |