RCT (Randomized Controlled Trial) of IV Acetaminophen for Post Cesarean Pain Relief

Randomized Control Trial of IV Acetaminophen for Post Cesarean Delivery Pain Relief

This study is being done to evaluate the scheduled use of intravenous (IV) acetaminophen among cesarean section patients. The study hopes to find out if patients who receive scheduled IV acetaminophen for 48 hours following delivery have lower self-reported pain scores and use less narcotic pain medication than patients who do not receive IV acetaminophen.

See Brief Summary

Inclusion Criteria:

• Age greater than or equal to 18 years
• Scheduled cesarean section delivery
• Patient of TriHealth's Faculty Medical Center or Tri-State Maternal Fetal Medicine Associates
• Singleton pregnancy
• Term delivery (greater than or equal to 37 weeks)
• Spinal/epidural anesthesia with epidural analgesia (duramorph)
• Use of pfannenstiel incision

Exclusion Criteria:

• Weight less than 50 kg
• Allergy to study drugs (acetaminophen, oxycodone, duramorph, NSAIDS)
• Multiple gestation pregnancy
• Cesarean section for pre-term delivery (less than 37 weeks)
• Fetal anomalies
• Inability to use epidural duramorph at time of procedure
• General anesthesia used
• Vertical skin incision
• Opioid addiction
• Liver dysfunction (hepatitis, HELLP (hemolysis, elevated liver enzymes, and low platelet count), preeclampsia)