Carbetocin Versus Syntometrine for Prevention of Postpartum Hemorrhage After Cesarean Section

Carbetocin Versus Syntometrine for Prevention of Postpartum Hemorrhage After Cesarean Section

to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of Postpartum hemorrhage after cesarean section

A double blind randomized study conducted on 450 pregnant subjected randomly either to single 100 μg IV dose of carbetocin (150 women) or combination of 5 IU oxytocin and 0.2 mg ergometrine (300 women) after fetal extraction and before placental removal.

Prevention of postpartum haemorrhage (PPH) after cesarean section (CS) had been evaluated by measurement of drop of Hemoglobin and hematocrit, incidence of PPH and number of subjects needed additional oxytocic

Inclusion Criteria:

• All participants are at 37 - 40 weeks of gestational age
• Noncomplicated pregnancy.

Exclusion Criteria:

• Participants with placenta previa
• Patients with coagulopathy
• preeclamptic women
• known sensitivity to oxytocin or methergine were excluded