Transfusion Requirements in Cardiac Surgery III | NCT02042898 | Trialant

Transfusion Requirements in Cardiac Surgery III | NCT02042898 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Restrictive transfusion strategy	Active Comparator	Restrictive transfusion strategy: patients will receive a red cell transfusion if their hemoglobin is <75 g/L (<7.5 g/dL;<4.7mmol/L) intraoperatively and/or postoperatively	Other: Restrictive Transfusion Strategy
Liberal transfusion strategy	Active Comparator	Liberal transfusion strategy: patients will receive a red cell transfusion if their hemoglobin concentration is <95 g/L (<9.5 g/dL<5.9mmol/L) intraoperatively, or postoperatively in the intensive care unit; and/or <85 g/L (< 8.5 g/dL;<5.3mmol/L) on the ward.	Other: Liberal transfusion strategy

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Composite score of any one of the following: (1) all-cause mortality; (2) myocardial infarction; (3) new renal failure requiring dialysis; or (4) new focal neurological deficit	Composite score of any one of the following events occurring during the index hospitalization (from the start of surgery until hospital discharge or postoperative day 28, whichever comes first): (1) all-cause mortality; (2) myocardial infarction; (3) new renal failure requiring dialysis; or (4) new focal neurological deficit	Up to hospital discharge or postoperative day 28 (whichever occurs first)

Secondary Outcomes

Measure	Description	Time Frame
Incidence of in-hospital all-cause mortality		Up to hospital discharge or postoperative day 28 (whichever occurs first)
Incidence of in-hospital myocardial infarction		Up to hospital discharge or postoperative day 28 (whichever occurs first)

Contacts/Locations Module

Overall Officials

Name	Affiliation	Role
David Mazer, MD	Unity Health Toronto	Principal Investigator
Nadine Shehata, MD	MOUNT SINAI HOSPITAL	Principal Investigator
Richard Whitlock, MD	McMaster University	Principal Investigator
Dean Fergusson, MD	Ottawa Hospital Research Institute	Principal Investigator
Kevin Thorpe, MSc	University of Toronto	Principal Investigator

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
41114449	Derived	Carson JL, Stanworth SJ, Dennis JA, Fergusson DA, Pagano MB, Roubinian NH, Turgeon AF, Valentine S, Trivella M, Doree C, Hebert PC. Transfusion thresholds and other strategies for guiding red blood cell transfusion. Cochrane Database Syst Rev. 2025 Oct 20;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub6.
37575193	Derived