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| ID | Type | Description | Link |
|---|---|---|---|
| 9540 |
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The purpose of this study is to determine whether a less restrictive strategy of red blood cell transfusion in elderly patients following coronary bypass surgery results in enhanced postoperative recovery as determined by quality of life assessment, exercise tolerance and clinical outcomes.
Two postoperative transfusion strategies:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liberal Red cell transfusion arm | Active Comparator | Transfusion if Hgb <100g/L |
|
| Restrictive Red Cell transfusion | Active Comparator | Transfusion if Hgb <70g/L |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood Transfusion | Procedure | Blood transfusion will be administered when the transfusion trigger is met. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Distance walked during 6 minute walk test at 5 weeks postop | 5 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| renal failure, hospital length of stay, Quality of Life questionnaire | during hospital stay |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mary Lee Myers, MD FRCSC | London Health Sciences Centre/University of Western Ontario | Principal Investigator |
| Robin Varghese, MD MS FRCSC | London Health Sciences Centre/University of Western Ontario | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| London Health Sciences Centre - University Campus | London | Ontario | N6A 5A5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41114449 | Derived | Carson JL, Stanworth SJ, Dennis JA, Fergusson DA, Pagano MB, Roubinian NH, Turgeon AF, Valentine S, Trivella M, Doree C, Hebert PC. Transfusion thresholds and other strategies for guiding red blood cell transfusion. Cochrane Database Syst Rev. 2025 Oct 20;10(10):CD002042. doi: 10.1002/14651858.CD002042.pub6. |
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| ID | Term |
|---|---|
| D000740 | Anemia |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D001803 | Blood Transfusion |
| ID | Term |
|---|---|
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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