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Before la surgery:
Transthoracic cardiac echography will be done systematically, to measure among other things the size of the left atrium.
During surgery:
Surgery under extracorporeal circulation: tissue samples will be harvested from the right atrium (one before clamping of the aorta (T0= pre-ischemia sample), immediately before declamping of the aorta (T1= post-ischemia sample).
Surgery without extracorporeal circulation: tissue samples from the right atrium before CABG (T0) and a second sample after CABG (T1).
In parallel with the harvesting of cardiac tissue, blood samples will be taken at different times (H0, H3, H24) to correlate tissue data with systemic data. These will be taken by the anesthetists.
After the surgery:
Holter ECG will be set up for 7 days of continuous recording. Each patient will fill in an observation notebook. The biological samples will be analysed immediately and the biological data obtained will be recorded in the observation notebook.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients about to undergo heart surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tissue samples from the right atrium | Other |
| ||
| Blood samples |
| Measure | Description | Time Frame |
|---|---|---|
| Onset or a de novo episode of atrial fibrillation during the 7 days following heart surgery | 7 days post-surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Markers of ischemia: circulating Troponin I before the surgery and at the end of the procedure | Baseline and at the end of surgery (15 minutes after unclamping when extracorporeal circulation) |
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Inclusion Criteria:
Exclusion Criteria:
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Coronary artery bypass graft with or without extracorporeal circulation
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de DIJON | Dijon | 21079 | France |
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| Other |
|
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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