Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Leatherhead Food Research | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The effects of two palaeolithic-type meals will be assessed with respect to a panel of gut hormones, satiety, blood glucose and insulin levels as compared to a meal constructed along the lines of the world Health Organisation dietary recommendations
In the current study the effects of two palaeolithic-type meals will be assessed with respect to a panel of gut hormones (including incretins), satiety, blood glucose and insulin levels.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PAL-2 | Experimental | Based on WHO dietary guidelines for protein, fat and carbohydrate but made with ingredients that would have been available in palaeolithic times (e.g. no cereals, no dairy). |
|
| TFH-1 | Experimental | Based on WHO dietary guidelines for protein, fat and carbohydrate but made with ingredients that would have been available in palaeolithic times, (e.g. no cereals, no dairy). |
|
| Reference | Placebo Comparator | Meal based on WHO dietary guidelines for protein, fat and carbohydrate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PAL-2 | Other | meal |
| |
| TFH-1 |
| Measure | Description | Time Frame |
|---|---|---|
| Glucagon-like peptide-1 | Area under the Concentration versus time curve for Glucagon-like peptide-1 in blood plasma | 0-3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose-dependent Insulinotropic Peptide | Area under the Concentration versus time curve of Glucose-dependent Insulinotropic Peptide in blood plasma | 0-3 hours |
| Fullness | Area under the curve for fullness scores (as rated by the subjects on a Visual Analog Scale) versus time |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin/glucose ratio | Ratio between insulin and glucose in blood as measured at 30 minutes after start of test product intake | 30 minutes |
| Ad libitum meal | Weight of an ad libitum pasta with tomato sauce meal consumed at 4 hours after test product intake |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Carmen Diaz-Toledo Trenado | Leatherhead Food Research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Leatherhead Food Research | Leatherhead | Surrey | KT22 7RY | United Kingdom |
Not provided
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Other |
Meal |
|
| Reference | Other | Meal |
|
| 0-4 hours |
| Glucose | Area under the Concentration versus time curve of Glucose in blood | 0-3 hours |
| Insulin | Area under the Concentration versus time curve of insulin in blood plasma | 0-3 hours |
| Glucagon | Area under the Concentration versus time curve of Glucagon in blood plasma | 0-3 hours |
| Peptide YY | Area under the Concentration versus time curve of Peptide YY in blood plasma | 0-3 hours |
| Hunger | Area under the curve for hunger scores (as rated by the subjects on a Visual Analog Scale) versus time | 0-4 hours |
| Desire to eat | Area under the curve for desire to eat scores (as rated by the subjects on a Visual Analog Scale) versus time | 0-4 hours |
| 4 hours |
| Time to return to baseline of satiety score for fullness, hunger and desire to eat | Time to return to baseline for the scores on a Visual Analogue Scales for fullness, hunger and desire to eat | up to 4 hours |
| Peptide hormones | Area under the Concentration versus time curve for total amylin, ghrelin, pancreatic polypeptide, C-peptide, leptin, interleukin-6, monocyte chemotactic protein-1 and tumour necrosis factor-alpha in blood plasma | 0-3 hours |