Prothrombotic Factors and Anaesthesia in Prostate Cancer

Prothrombotic Factors , Angiogenic Growth Factor and Different Anaesthetic Techniques in Cancer Patients Undergoing Prostatectomy

This study aims to assess if different anesthetic techniques can affect coagulant factors in patients with prostate cancer undergoing elective laparoscopic radical prostatectomy (LRP).

The utility of anti-thrombotic prophylaxis in cancer patients undergoing laparoscopic radical prostatectomy (LRP) is still controversial. Moreover, different anaesthetic techniques could modify coagulant factors. Thus, in this study we will be to investigate the variations of pro- and anti-coagulant and fibrinolytic factors in two established types of anaesthesia in patients with prostate cancer undergoing elective LRP.

Inclusion Criteria:

• newly diagnosed cancer of the prostate
• histological Gleason score evaluation.

Exclusion Criteria:

• ASA >2
• metabolic equivalent task < 4
• BMI>30
• no pre-operative pharmacological thromboprophylaxis and/or anti-coagulant therapy
• history of abnormal bleeding, or abnormal coagulant factors
• sepsis within the last 2 weeks
• previous new adjuvant treatments (chemo, hormone, and radiotherapy)
• non-steroid , anti-inflammatory and statins drugs for at least 2 wks before surgery
• venous or arterial thromboembolism within the last 3 months, peripheral venous disease
• neurological disease with extremity paresis
• chronic liver disease
• pre-operative haemoglobin concentration < 9 mg dl-1
• prolonged duration of surgery (>3 hrs)
• peri-operative blood transfusion
• not adequate material for laboratory testing