The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide in Patients Undergoing Laparoscopic Surgery

Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response.

Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane.

To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well.

Secondarily, kidney protection effect of propofol over desflurane will be compared.

Inclusion Criteria:

• patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia

Exclusion Criteria:

• chronic renal failure ( estimated glomerular filtration rate <60 mL/min/1.73m2)
• allergy to propofol, nuts
• on diuretics, vitamin C or vitamin E within 5 days before surgery
• Body mass index > 30 kg/m2
• older than 70 years
• who cannot read the patient consent form