The study is to show the prognostic factor of HRV parameter and cardiac fibrosis markers in critical illness patients

The analysis of Heart Rate Variability with 24hrs Holter ECG and serum cardiac fibrosis markers in critical illness patients who are with cardiogenic shock, with ECMO or IABP support, or with APACH II score >25)

Inclusion Criteria:

• critical illness patients who are with cardiogenic shock, with ECMO or IABP support, or with APACH II score >25)

Exclusion Criteria:

• pacemaker rhythm, not sign the permit

adult age>18 years old