Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation

Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation After DC Cardioversion

the purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion

Atrial fibrillation is the most common arrhythmia requiring continuous therapy. Conversion to and maintenance of sinus rhythm is important. Propafenone and dronedarone has been used as treatment for maintenance of sinus rhythm after DC cardioversion. But there are no direct comparison study.

The purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion.

Inclusion Criteria:

• a patient with persistent atrial fibrillation who received successful DC cardioversion

Exclusion Criteria:

• prior amiodarone use
• NYHA class III or IV heart failure
• Left ventricular ejection fraction < 35%
• second or third AV block
• sick sinus syndrome
• heart rate < 50 beat per minute
• myocardiac infarction within 3 months
• pregnant women
• severe hepatic dysfunction
• QT prolongation > 500ms or PR interval > 180ms
• history of hypersensitivity for drug