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The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial. The investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| electrical cardioversion | Experimental | Patients were sedated with propofol and external cardioversion was performed in anteroposterior position (right sternal body at the third intercostal space-angle of the left scapula). Patients were submitted to a biphasic wave-form sequential shock of 100-150-200 J, if necessary. |
|
| propafenone | Active Comparator | Propafenone (2 mg/kg bolus) was administered iv to obtain pharmacologic sinus rhythm conversion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| electrical cardioversion | Procedure | External cardioversion was performed in anteroposterior position (right sternal body at the third intercostal space-angle of the left scapula); patients were submitted to a biphasic wave-form sequential shock of 100-150-200 J, if necessary. |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm | during emergency department stay |
| Measure | Description | Time Frame |
|---|---|---|
| Number of adverse events related to electrical and pharmacological cardioversion | during emergency department stay | |
| recurrence of atrial fibrillation | within 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Emergency Unit - Valduce Hospital | Como | 22100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21422032 | Derived | Bellone A, Etteri M, Vettorello M, Bonetti C, Clerici D, Gini G, Maino C, Mariani M, Natalizi A, Nessi I, Rampoldi A, Colombo L. Cardioversion of acute atrial fibrillation in the emergency department: a prospective randomised trial. Emerg Med J. 2012 Mar;29(3):188-91. doi: 10.1136/emj.2010.109702. Epub 2011 Mar 21. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 14, 2009 | |
| Reset | Jul 29, 2010 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 14, 2009 | Jul 29, 2010 |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D004554 | Electric Countershock |
| D011405 | Propafenone |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D011427 | Propiophenones |
| D007659 | Ketones |
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| propafenone | Drug | Propafenone (2 mg/kg bolus) was administered to obtain pharmacolgic sinus rhythm conversion. |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D009930 |
| Organic Chemicals |