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| ID | Type | Description | Link |
|---|---|---|---|
| U1111-1132-2061 | Other Identifier | Universal trial number |
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| Name | Class |
|---|---|
| Instituto Nacional de Cardiologia de Laranjeiras | OTHER |
| Oswaldo Cruz Foundation | OTHER |
| Rio de Janeiro State Research Supporting Foundation (FAPERJ) | OTHER_GOV |
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The purpose this research is to check the effect of Brazil Nuts consumption in oxidative stress, metabolic abnormalities and microvascular endothelial function dyslipidemic and hypertensive patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cassava flavored flour | Placebo Comparator | The placebo group (cassava flour flavored) received 9g/day of cassava flour flavored during three months (12 weeks) |
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| Brazil nut flour | Experimental | The Brazil nut group received 13g/day of Brazil nut flour during three months (12 weeks) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brazil nut flour | Dietary Supplement | The Brazil nut group received 13g/day of Brazil nut flour during three months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Antioxidant biomarker | Change from Baseline plasma Gluthathione Peroxidase activity (nmol/min/ml) at 12 weeks, samples were stocked at -80 degrees. | Change from Baseline at 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Oxidative stress biomarker | The change from baseline plasma 8-isoprostane (pg/ml) at 12 weeks, samples were stocked at -80 degrees. | Change from Baseline at 12 weeks. |
| microvascular endothelial function |
| Measure | Description | Time Frame |
|---|---|---|
| Anthropometric measures | body weight (kg), body mass index (kg/m2) and waist circumference (cm). | Change from baseline at 12 weeks |
| Blood lipids | total Cholesterol (mg/dl), LDL-cholesterol (mg/dl), HDL-cholesterol (mg/dl) and triglycerides (mg/dl). |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Grazielle V B Huguenin, Nutricionist | Universidade Federal do Rio de Janeiro | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26077768 | Derived | Carvalho RF, Huguenin GV, Luiz RR, Moreira AS, Oliveira GM, Rosa G. Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial. Nutr J. 2015 Jun 16;14:59. doi: 10.1186/s12937-015-0036-x. | |
| 26022214 | Derived | Huguenin GV, Oliveira GM, Moreira AS, Saint'Pierre TD, Goncalves RA, Pinheiro-Mulder AR, Teodoro AJ, Luiz RR, Rosa G. Improvement of antioxidant status after Brazil nut intake in hypertensive and dyslipidemic subjects. Nutr J. 2015 May 29;14:54. doi: 10.1186/s12937-015-0043-y. |
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| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| ID | Term |
|---|---|
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Placebo (cassava flavored flour) | Dietary Supplement | The group placebo (cassava flour flavored)received 9g/day of cassava flour flavored during three months |
|
Microvascular reactivity was evaluated using an Laser Speckle Contrast Imaging system with a laser wavelength of 785 nm in combination with the iontophoresis (increasing anodal currents of 30, 60, 90, 120, 150 and 180μA for 10 second intervals spaced 1 minute apart) of acetylcholine (2% v/v) for the noninvasive and continuous measurement of cutaneous microvascular perfusion changes measured in arbitrary perfusion units.
| Change from baseline at 12 weeks |
| Change from baseline at 12 weeks |