The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Pilot Study in Normo-responder IVF Patients

The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Randomized Controlled Pilot Study in Normo-responder IVF Patients

After hCG trigger a large amount of exogenous progesterone is used for luteal phase support in many countries until 10th week of gestation. Instead we suggest the use of two small doses of hCG after the trigger during the early luteal phase after GnRHa trigger, promoting the endogenous progesterone production from the corpora lutea (CL).

Inclusion Criteria:

• Age between 20 and 40
• Normal menstrual cycles: 25-34 days
• Oligomenorrhea/amenorrhea or polycystic syndrome (defined according to the Rotterdam criteria 2004)
• BMI >18 and <35 kg/m2

Exclusion Criteria:

• Patients with >14 follicles on day of trigger
• Previous hyperresponse with OHSS development
• Previous low response (less than 3 oocytes on a high dose of FSH stimulation)
• Endocrine disorders