General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

Inclusion Criteria:

• patients with Colorectal Cancer(CRC);
• subjected to the Fast-Track processing of surgery;
• between 18 and 75 years old.

Exclusion Criteria:

• American Society of Anesthesiologists(ASA) grade > III;
• BMI > 30;
• a history of abdominal surgery, endocrine or immune system dysfunction;
• recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month;
• previous contraindication to epidural anesthesia.