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| ID | Type | Description | Link |
|---|---|---|---|
| RJpancreatitis01 | Registry Identifier | RuijinH |
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| Name | Class |
|---|---|
| RenJi Hospital | OTHER |
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To compare different goals of fluid resuscitation in early stage of acute pancreatitis
With regard to study of sepsis and several studies of SAP demonstrating the deleterious effects of fluid loss and haemoconcentration within the first 24h after admission（or onset of abdominal pain）, early goal-directed fluid resuscitation has the potential of improving outcome also in SAP. But the goal of fluid resuscitation remained controversial.Several criteria of fluid resuscitation had been described. Ours had been described in previous study, and had shown a ideal result with less incidence of abdominal compartment syndrome and higher survival rate. This study aims to determine a better goal of fluid resuscitation in severe acute pancreatitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Goal A | Active Comparator | controled fluid therapy: 5~10ml/kg/hr fulfillment of two or more of four criteria:
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| Goal B | Other | controled fluid therapy: 5~10ml/kg/hr fulfillment of all of the following criteria: 1 central venous pressure8-12 mmHg , 2.mean arterial pressure 65-85 mm Hg, 3. urine output ≥0.5 ml/kg/h 4. ScvO2 ≤70% |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Goal A | Other | controled fluid therapy：10~5ml/kg/h，crystalloid vs colloid 2:1 resuscitation target： fulfillment of two or more of four criteria:1. HR <120 beats/min, 2.MAP 65-85 mm Hg, 3. urine output ≥1 ml/kg /h 4. HCT ≤35%. |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | 28day |
| Measure | Description | Time Frame |
|---|---|---|
| intra-abdominal Hypertension | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| respiratory failure | 14days |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhen er Chen, PhD | Contact | 64370045 | 665520 | chenerzhen@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Qiang En Mao, PhD | Emergency intensive care unit of Ruijin Hospital | Study Director |
| Ming zhong, MD | doctor | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ruijin | Recruiting | Shanghai | Shanghai Municipality | 20000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19187641 | Background | Mao EQ, Tang YQ, Fei J, Qin S, Wu J, Li L, Min D, Zhang SD. Fluid therapy for severe acute pancreatitis in acute response stage. Chin Med J (Engl). 2009 Jan 20;122(2):169-73. |
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| ID | Term |
|---|---|
| D010195 | Pancreatitis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
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| Goal B | Other | controled fluid therapy：10~5ml/kg/h，crystalloid vs colloid 2:1 resuscitation target： fulfillment of all of the following criteria: 1 CVP 8-12 mmHg , 2.MAP 65-85 mm Hg, 3. urine output ≥0.5 ml/kg/h 4. ScvO2 ≤70% |
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