Goal-directed Fluid Resuscitation in Acute Pancreatitis

A Randomized-controlled Trial of a Targeted Approach to Fluid Resuscitation in Acute Pancreatitis

Vigorous fluid resuscitation is currently believed to play a key role in reducing complications associated with acute pancreatitis. However, aggressive fluid replacement can be associated with complications such as pulmonary fluid sequestration. The purpose of this study is to evaluate alternative approaches to early fluid resuscitation for patients with acute pancreatitis.

Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis.

Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to normal saline on systemic inflammation in acute pancreatitis.

Inclusion Criteria:

• acute pancreatitis diagnosed by at least 2 criteria
• adult patients at least 18 years of age

Exclusion Criteria:

• history of severe cardiovascular, respiratory, renal, hepatic or hematologic/immunologic disease
• concurrent metabolic or physiologic derangement requiring specific fluid management
• pregnancy
• patients transferred from acute care hospital