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This is a cross-sectional pilot study to assess coronary artery disease with minimal invasive techniques in patients with asymptomatic troponin elevation after noncardiac surgery. The primary objective is to quantify coronary artery disease, as determined by coronary CT and MR, as a cause of postoperative myocardial injury. The secondary objective is to correlate coronary calciumscore to postoperative levels of troponin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1. TnI elevation | Experimental | TnI 0.06-0.60ng/ml, no ischemia on ECG. Intervention: minimal invasive cardiac imaging |
|
| 2. TnI elevation | Experimental | TnI 0.61-6.00 ng/ml, no ischemia on ECG. Intervention: minimal invasive cardiac imaging |
|
| 3. TnI elevation | Experimental | TnI>6.00 ng/ml, no ischemia on ECG. Intervention: minimal invasive cardiac imaging |
|
| 4. TnI elevation | Experimental | TnI >6.00 ng/ml, ischemia on ECG and Hb<5.1. Intervention: minimal invasive cardiac imaging |
|
| 5. TnI elevation | Experimental | TnI >6.00 ng/ml, ischemia on ECG and Hb>5.0. Intervention: minimal invasive cardiac imaging |
|
| Control |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Minimal invasive cardiac imaging | Other |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Coronary artery disease | Coronary artery disease with luminal narrowing > 50 % in one or more major epicardial vessels by CCTA. | During hospital admission |
| Measure | Description | Time Frame |
|---|---|---|
| Coronary calcium score | Agatston coronary calcium score | During hospital admission |
| Extent of coronary artery atherosclerosis | Presence and extent of coronary artery atherosclerosis as measured with coronary CCTA |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hendrik M. Nathoe, MD PhD | Contact | +31 88 755 7273 | H.M.Nathoe@umcutrecht.nl |
| Name | Affiliation | Role |
|---|---|---|
| Hendrik M. Nathoe, MD PhD | UMC Utrecht | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UMC Utrecht | Recruiting | Utrecht | Utrecht | Netherlands |
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TnI <0.06 ng/ml, no ischemia on ECG. Intervention: minimal invasive cardiac imaging |
|
| During hospital admission |
| Minimal myocardial injury | Minimal myocardial injury measured by late gadolinium enhancement on CMR. | During hospital admission |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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