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| ID | Type | Description | Link |
|---|---|---|---|
| HCPA | Other Identifier | Hospital de ClÃnicas de Porto Alegre |
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This study is intended to evaluate ovarian cells after being submitted do different in vitro fertilization protocols. The investigators will analyze hormones secretion and intracellular mechanisms of these cells comparing the GnRH agonist protocol and the GnRH antagonist protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GnRH Agonist | Active Comparator | GnRH long agonist protocol of invitro fertilization |
|
| GnRH Antagonist | Active Comparator | GnRH fixed antagonist protocol of in vitro fertilization |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| randomization between the two GnRH analogues (agonist and antagonist) | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of steroid secretion and enzyme expression in in vitro luteinized granulosa cells | evaluation of granulosa cells hormone secretion and enzyme expression in media culture 48 hours after ovarian punction | after 48h in media culture |
| Number of retrieved oocytes | Immediately after the ovarian punction the number of retrieved oocytes will be evaluated | After the ovarian punction |
| Measure | Description | Time Frame |
|---|---|---|
| number of embryos | the embryologist will verify the number of embryos after 3 to 5 days from the ovarian punction | 3 to 5 days after ovarian punction |
| Subgroup analyses comparing FSH versus HMG protocols |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rita d Chapon | Contact | 5192028288 | rchapon@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Projeto Cegonha | Recruiting | Porto Alegre | Rio Grande do Sul | 90020160 | Brazil |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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It will be verified the differences between the two types of gonadotrophins in ovarian stimulation regarding: units of gonadotrophins used, number of retrieved oocytes,number of embryos and embryo score
| after ovarian punction |
| Insemine | Recruiting | Porto Alegre | Rio Grande do Sul | 91330001 | Brazil |
|