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| Name | Class |
|---|---|
| Fundação de Amparo à Pesquisa do Estado de São Paulo | OTHER_GOV |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico | OTHER_GOV |
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The investigators hypothesis that exercise training would potentiate the effects of cardiac resynchronization therapy in heart failure patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy People | No Intervention | Control group | |
| Untrained CRT | Experimental | Untrained CRT patients |
|
| Exercise trained + CRT | Experimental | Exercise-trained CRT patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise training and/or CRT | Other | Three 40-minute exercise sessions per week on a treadmill for four months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sympathetic nerve activity | Sympathetic nerve activity will be assessed by microneurography | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Peak oxygen consumption | Peak oxygen consumption will be determined by cardiopulmonary exercise testing | 4 months |
| Quality of life | Quality of life will be assessed by questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Carlos E Negrao, Phd | InCor, HCFMUSP | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thais Simoes Nobre Pires Santos | São Paulo | São Paulo | 05403-000 | Brazil |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 4 months |
| Blood inflammatory markers | Blood inflammatory markers will be assessed by venipuncture | 4 months |
| skeletal muscle strength | Muscular evaluation will be done muscle gene expression | 4 months |
| Muscle Blood Flow | Forearm blood flow will be assessed by venous occlusion plethysmography | 4 months |