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| Name | Class |
|---|---|
| Wu Jieping Medical Foundation | OTHER |
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The purpose of this study is to determine the feasibility and efficacy of preoperative nimotuzumab injection combined with concurrent chemoradiotherapy for initially inoperable, locally advanced cervical cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nimotuzumab+chemoradiotherapy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nimotuzumab+chemoradiotherapy | Other | Nimotuzumab 200mg per week will be administered concurrent with platinum-based chemotherapy and intensity-modulated radiation therapy. After the preoperative treatment, patients will be assessed for tumor response and operability. For those who are considered to be candidates for operation, radical surgery will be performed. -------------------------------------------------------------------------------- |
| Measure | Description | Time Frame |
|---|---|---|
| Treatment related toxicities | Acute and chronic toxicities. | at 1 year |
| Tumor response after preoperative treatment | assessed at 4-5 weeks after the completion of preoperative treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Progression-free survival | at 1 year | |
| Overall survival | at 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Heming Lu, MS | Contact | +86-771-218-6503 | gxheminglu@sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Heming Lu, MS | People's Hospital of Guangxi Zhuang Autonomous Region | Study Chair |
| Heming Lu, MS | People's Hospital of Guangxi Zhuang Autonomous Region | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| People's Hospital of Guangxi Zhuang Autonomous Region | Recruiting | Nanning | Guangxi | 530021 | China |
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| ID | Term |
|---|---|
| D002583 | Uterine Cervical Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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|
| Yun Mo, MS |
| People's Hospital of Guangxi Zhuang Autonomous Region |
| Principal Investigator |
| D009369 |
| Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |