Preoperative Chemoradiotherapy Combined With Nimotuzumab for Cervical Cancer

Preoperative Concurrent Chemoradiotherapy Combined With Nimotuzumab Injection for Locally Advanced Cervical Cancer: a Phase II Study

The purpose of this study is to determine the feasibility and efficacy of preoperative nimotuzumab injection combined with concurrent chemoradiotherapy for initially inoperable, locally advanced cervical cancer.

Inclusion Criteria:

• Histologically or cytologically proven squamous cell cervical cancer
• Stages IB2-IIIB according to FIGO Staging System
• Age:18-75
• ECOG<2
• Normal bone marrow function
• Initial assessed and considered not candidates for operation
• Signed study-specific consent form

Exclusion Criteria:

• Pregnant or lactating women
• Patients with other malignancies
• Patients who received radiotherapy or chemotherapy previously
• Presence of uncontrolled life-threatening illness
• Allergy to platinum or monoclonal antibody