The purpose of this phase II trial is to determine the feasibility and efficacy of nimotuzumab injection combined with concurrent chemoradiotherapy for initially inoperable locally advanced cervical cancer.

For locally advanced cervical cancer, radical radiation with concurrent chemotherapy remains the standard treatment recommended by NCCN. However, in more than 35% of cases, tumor persistence recurrence or metastasis would occur after chemoradiation. Nimotuzumab, belongs to anti-EGFR monoclonal antibodies, has proved to be useful in multiple solid tumors, such as NPC, colorectal cancer, etc.

In recent years, nimotuzumab was also applied in recurrence or metastasis cervical cancer. It was proved to be well tolerated and might have a role in the treatment of advanced cervical cancer. However, there is no publication about nimotuzumab used in locally advanced cervical cancer.

Inclusion Criteria:

• 18 Years to 70 Years，female
• Histological diagnosis of squamous cell carcinoma of cervix, FIGO stage IIB-IVA,with diameter 4-6 cm, without distant metastasis.
• no chance of surgery confirmed by more than two deputy chief doctors of gynecology.
• Moderate or high expression of EGFR
• The function of main organ is normal, including blood, heart, lung, liver, and kidney. Without history of hypertension, stroke. Blood pressure is normal before treatment.
• WBC≥3.5×10E9/L，ANC≥1.5×10E9/L；HB≥90g/L，PLT≥100×10E9/L
• ALT, AST and Cr below 1.5 times of normal level
• Willing to accept treatment
• Ability to comply with trial requirements KPS≥70

Exclusion Criteria:

• Evidence of distance metastasis
• Impossible to measure the diameter of tumor, or the tumor is too huge (diameter>6cm)
• Couldn't examine with pelvic MRI due to a variety of reasons
• Used to treat with radiotherapy chemotherapy or molecular target therapy and immune therapy
• Diagnosed with another malignant tumor in 5 years
• Used to be a volunteer of other clinical trial.
• Used to be allergic reaction with grade 3 or 4 degree to any experimental drugs
• Severe medical history of lung ,liver, kidney or heart.
• Active infection in any part of the whole body.
• Examination results showed radiotherapy contraindications