Optimizing Surgical Conditions During Gynecologic Laparoscopic Surgery With Deep Neuromuscular Blockade

Optimizing Surgical Conditions: Intraabdominal Distance During Gynecologic Laparoscopic Surgery With and Without Muscle Relaxation (The Measurement Study)

To investigate if deep neuromuscular blockade improves intraabdominal volume compared to no neuromuscular blockade in patients scheduled for gynecologic laparoscopic surgery with pneumoperitoneum 12 mmHg.

Hypothesis:

Deep neuromuscular blockade improves intraabdominal space (the distance from promontorium to skin surface, cm) compared to no neuromuscular blockade.

Inclusion Criteria:

• patients > 18 years old
• elective laparoscopic operation
• can read and understand Danish
• informed consent

Exclusion Criteria:

• BMI > 30 kg/cm2
• known allergy to medications that are included in the project,
• severe renal disease, defined by S-creatinine> 0,200 mmol/L, GFR < 30ml/min or hemodialysis),
• neuromuscular disease that may interfere with neuromuscular data,
• lactating or pregnant,
• impaired liver function,
• converting to laparotomy,
• perioperative use of neuromuscular blocking agents before randomization,
• pneumoperitoneum set to >12 mmHg on the insufflator