Exercise-induced Changes in DNA-methylation

The Effect of Exercise on Maximal Aerobic Capacity, DNA-methylation and Gene Expression in Healthy Elderly Men

The purpose of the study was to investigate whether regular moderate- or high-intensity interval training can change the DNA methylation in a long-lasting state, and whether these changes affect the gene expression. In addition, the investigators will determine whether the intensity of the training could be an affecting factor of the possible DNA-methylation change as well. The null hypothesis was that no such exercise-induced changes occur.

Inclusion Criteria:

• Male
• 70-75 years old
• Signed written informed consent

Exclusion Criteria:

• Incompatible with exercise
• Known cardiac disease
• Active cancer
• Significant pulmonary disease
• Uncontrolled hypertension
• Use of blood thinning medicine (except Albyl-E)
• Drug abuse
• Alcohol abuse
• Finishing less than 80% of the exercise sessions (this complies to the training groups)