Phase II Randomized Placebo-controlled Study With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis

Phase 2 Study Randomized Placebo Controlled With Vitamin K2 in Asymptomatic Calcified Carotid Stenosis

Randomized placebo-controlled study with vitamine K2 (Menaquinone-4) in calcified carotid stenosis. We evaluate the plaque remodelling after administration of vitamine, reducing the calcified component.

Inclusion Criteria:

• carotid stenosis between 50 and 70% (NASCET criteria) with calcified plaque

Exclusion Criteria:

• renal and/or hepatic failure
• diseases with secondary calcifications
• dementia
• previous strokes
• concomitant use of anticoagulants
• concomitant infections
• pregnancy or breastfeeding
• reduced patient's compliance