Concomitant Therapy of H. Pylori

Evaluation of the Efficacy of Concomitant Therapy for Eradication of Helicobacter Pylori

If we compare eradication rate of Helicobacter pylori divided to 4 groups: amoxicillin, rabeprazole, clarithromycin(AOC), amoxicillin, rabeprazole, metronidazole(AOM), treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days(sequential), amoxicillin, clarithromycin, metronidazole, rabeprazole(concomitant), then the eradication rate of concomitant group will be the highest.

• Subject: The patient of gastritis, gastric ulcer, and duodenal ulcer infected with Helicobacter pylori
• 170 subjects per group
• Eradication regimens are as follows: AOC group, treated with amoxicillin, rabeprazole, clarithromycin for 7 days; AOM group, treated with amoxicillin, rabeprazole, metronidazole for 7 days; sequential group, treated with amoxicillin, rabeprazole for 5 day, followed by clarithromycin, metronidazole, rabeprazole for 5 days; concomitant group, treated with amoxicillin, clarithromycin, metronidazole, rabeprazole for 7 days

Inclusion Criteria:

• patients infected with Helicobacter pylori

Exclusion Criteria:

• cancer
• pregnancy
• formerly treated with eradication