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IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | 0.9% Normal Saline is given instead of Lidocaine in the same volume and duration. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. | |
| Lidocaine 1mg/kg | Active Comparator | Lidocaine 1mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. |
|
| Lidocaine 1.5mg/kg | Active Comparator | Lidocaine 1.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. |
|
| Lidocaine 2mg/kg | Active Comparator | Lidocaine 2mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. |
|
| Lidocaine 2.5mg/kg | Active Comparator | Lidocaine 2.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine 1mg/kg | Drug | The total dosage of Etomidate needed for induction of anesthesia is recorded at last. |
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| Measure | Description | Time Frame |
|---|---|---|
| changes in blood pressure and heart rate. | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Liu Jin, MD | West China Hospital | Study Director |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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|
| Lidocaine 1.5mg/kg | Drug | same as other |
|
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| Lidocaine 2mg/kg | Drug | same as other |
|
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| Lidocaine 2.5mg/kg | Drug | same as other |
|
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| Aniline Compounds |
| D000588 | Amines |