The rationale for this trial is to apply a simple and minimally strenuous pre-screening approach prior to performing more extensive trial-specific screening and baseline-characterization activities in the resulting pre-selected population of subjects.

The pre-screening assessments are designed to characterize the metabolic risk profile / prediabetic status in an unselected population of overweight and obese volunteers, aiming to pre-select high risk and prediabetic subjects as a target population who may specifically profit from primary diabetes intervention (prevention) strategies.

Inclusion Criteria:

• Obese and overweight subjects
• Considered generally healthy

Exclusion Criteria:

• Clinically significant acute illness within 2 weeks before study procedures

Generally healthy or Type 2 Diabetes mellitus