Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Adipocytokines play an important role in joint inflammation in patients with knee osteoarthritis as measured by ultrasound and high sensitivity protein-C reactive. Adipocytokines could be the link between osteoarthritis and cardiovascular risk factors more prevalent in these patients.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inflammatory knee osteoarthritis | One group of patients with inflammatory condition in physical evaluation. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed. |
| |
| Non-inflammatory knee osteoarthritis | Patients with no inflammatory condition in physical examination. We will make a blood analyse and arthrocentesis when synovial fluid were found in ultrasound examination. Ultrasound of affected knee and carotid artery will be performed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood analyse, arthrocentesis, ultrasound examination | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| adipocytokine level | We will determine the adipocytokine level at the end of inclusion period between 12-18 months | 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Ultrasound inflammatory exploration of the knee | we evaluate the presence of synovial fluid with ultrasound evaluation in the visit of the patient. Ultrasound evaluation will be performed by two Rheumatologists. | 18 months |
| Ultrasound of carotid artery |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
patients over 50 years who were referred for rheumatology for symptomatic knee osteoarthritis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joan Calvet, Dr | Contact | 0034 937231010 | 24065 | joan.calvet.fontova@gmail.com |
| Cristobal Orellana, Dr | Contact | 0034 937231010 | 24059 | cristobalorellana1@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| jordi Gratacos, MD Ph | Hospital Parc Tauli | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Parc Tauli Sabadell | Recruiting | Sabadell | Barcelona | 08208 | Spain |
Not provided
| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| D004700 | Endocrine System Diseases |
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D000069237 | Arthrocentesis |
| ID | Term |
|---|---|
| D019152 | Paracentesis |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
Not provided
Not provided
Not provided
Not provided
Not provided
First we analyze the blood and articular fluid adipocytokines. If we can define a subset of patients characterized by a pattern of adipocytokines, genetic analysis will be performed later.
We will evaluate patients with ultrasound exploration in order to describe the presence of atheromatous disease in the visit of the patient |
| 18 months |
| Cardiovascular risk factors | We evaluate the prevalence of cardiovascular risk factors in the symptomatic knee osteoarthritis patients, and the relationship with adipocytokines. We will evaluate blood analyse levels of cholesterol, glycemia. | 18months |
| Hospital Parc Tauli | Recruiting | Sabadell | Barcelona | 08208 | Spain |
|
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |