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The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.
The aim of the study is to investigate whether the expression and production of four adipokines [adiponectin, omenin-1, resistin and retinol binding protein-4 (RBP4)] secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis. Specifically, this study aims to investigate whether the expression and production of these adipokines is different between two sites of the heart, that are perfused by coronary arteries with different degrees of stenosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NonDM-0 | Nondiabetics without significant stenoses (> 50%) in the coronary arteries | ||
| NonDM-L | Nondiabetics with significant stenosis in the left anterior descending (LAD) coronary artery or in the Left main (LM) coronary artery, but without significant stenosis in the right coronary artery (RCA) | ||
| NonDM-R | Nondiabetics without significant stenosis in the LAD and in the LM, but with significant stenosis in the RCA | ||
| NonDM-LR | Nondiabetics with significant stenosis in the LAD or in the LM and with significant stenosis in the RCA | ||
| DM-0 | Patients with type 2 diabetes mellitus (T2DM) without significant stenoses in the coronary arteries | ||
| DM-L | T2DM patients with significant stenosis in the LAD or in the LM, but without significant stenosis in RCA | ||
| DM-R |
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| Measure | Description | Time Frame |
|---|---|---|
| Association between coronary artery disease and epicardial adipokines | Comparison of the mRNA and protein production of four adipokines [adiponectin, omentin-1, resistin, retinol binding protein-4(RBP4)] from the epicardial adipose tissue between the territories that are supplied by LAD and RCA. This comparison will be performed in the following clusters of groups:
| Baseline measurement |
| Measure | Description | Time Frame |
|---|---|---|
| Impact of diabetes on epicardial adipokines | Comparison of the mRNA and protein production of four adipokines (adiponectin, omentin-1, resistin, RBP4) from the epicardial adipose tissue of the territory that is supplied by LAD or RCA between the following groups:
| Baseline measurement |
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Inclusion Criteria:
1) Individuals undergoing cardiac surgery
Exclusion Criteria:
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Individuals undergoing cardiac surgery will be recruited in this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Eustratios Apostolakis, Professor | Contact | 0030 2651099679 | stratisapostolakis@yahoo.gr |
| Name | Affiliation | Role |
|---|---|---|
| Eustratios Apostolakis, Professor | University Hospital, Ioannina | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Ioannina | Recruiting | Ioannina | Greece |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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T2DM patients without significant stenosis in the LAD and in the LM, but with significant stenosis in the RCA
| DM-LR | T2DM patients with significant stenosis in the LAD or in the LM and with significant stenosis in the RCA |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |