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This study is aimed at assessing how Roux-en-Y gastric bypass (RYGP) impacts on energy and nutrients' intake, energy expenditure, and nutritional status in obese patients. It will try quantitate energy and protein balance after RYGP, and to identify how RYGP effects the intake of various common dietary protein sources 16 female patients with BMI > 40 kg/m2 and on a waiting list for bariatric surgery will be included. The following measurements will be performed before, and 1, 3, 6, 12, and 36 months after RYGP
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| obese female subjects | 16 obese female subjects with BMI > 40 kg/m2 on a waiting list for bariatric surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Roux-en-Y gastric bypass (RYGP) | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes in daily dietary protein intake | changes in 24-hour protein intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| changes in total energy intake | changes in 24-hour energy intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery |
| changes in basal metabolic rate |
| Measure | Description | Time Frame |
|---|---|---|
| changes in fasting, resting respiratory exchange ratio | measurement will be obtained by indirect calorimetry | measurements obtained baseline, and 3, 6, 12, and 36 months after RYGP |
| changes in 24-hour urinary urea excretion |
Inclusion Criteria:
Exclusion Criteria:
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16 female obese subjects on a waiting list for gastric bypass bariatric surgery
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| Name | Affiliation | Role |
|---|---|---|
| Vittorio Giusti, MD | CHUV | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical Research Centre, CHUV | Lausanne | CH-1011 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39351881 | Derived | Chakhtoura MT, Nakhoul NF, Akl EA, Safadi BY, Mantzoros CS, Metzendorf MI, El-Hajj Fuleihan G. Oral vitamin D supplementation for adults with obesity undergoing bariatric surgery. Cochrane Database Syst Rev. 2024 Oct 1;10(10):CD011800. doi: 10.1002/14651858.CD011800.pub2. | |
| 26675775 | Derived | Giusti V, Theytaz F, Di Vetta V, Clarisse M, Suter M, Tappy L. Energy and macronutrient intake after gastric bypass for morbid obesity: a 3-y observational study focused on protein consumption. Am J Clin Nutr. 2016 Jan;103(1):18-24. doi: 10.3945/ajcn.115.111732. Epub 2015 Dec 16. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D015390 | Gastric Bypass |
| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
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BMR will be measured by indirect calorimetry over a 45-90 min period |
| measurements obtained baseline , and 3, 6, 12, 36 months after surgery |
| changes in total energy intake | Changes in daily total energy intake will be evaluated by 7-day food diary; portion size will be assessed with the use of photographs from the SU.VI.MAX study | measurements obtained baseline , and 1,3, 6, 12, 36 months after surgery |
24-hour urine collections
| Measurements obtained baseline , and 3, 6, 12, 36 months after RYGP |
| 25306425 | Derived | De Giorgi S, Campos V, Egli L, Toepel U, Carrel G, Cariou B, Rainteau D, Schneiter P, Tappy L, Giusti V. Long-term effects of Roux-en-Y gastric bypass on postprandial plasma lipid and bile acids kinetics in female non diabetic subjects: A cross-sectional pilot study. Clin Nutr. 2015 Oct;34(5):911-7. doi: 10.1016/j.clnu.2014.09.018. Epub 2014 Sep 26. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005763 |
| Gastroenterostomy |
| D000714 | Anastomosis, Surgical |
| D013514 | Surgical Procedures, Operative |
| D013505 | Digestive System Surgical Procedures |