Vitamin D Supplementation for Bipolar Depression

Randomized Double-Blind Placebo-Controlled Pilot Study of Vitamin D Supplementation for the Treatment of Bipolar Depression

The purpose of this study is to whether vitamin d supplementation in those with low levels may reduce depression symptoms in people experiencing bipolar depression.

Inclusion Criteria:

• Adults >18years old
• Bipolar disorder (I,II or NOS),
• MADRS Score>7 (mild),
• 25(OH)D level <30ng/ml (insufficient).
• able to take the prescribed vitamin D by mouth

Exclusion Criteria:

Systemic diseases such as:

• liver and kidney diseases,
• known parathyroid disorder,
• disorders of vitamin D metabolism,
• taking vitamin D replacement therapy,
• fat digestion disorder,
• diabetes mellitus,
• gi surgery
• If the serum calcium in the range 2.50-2.55 mmol L, inclusion required a serum PTH below 5.0 pmol L-acute psychiatric urgency:
• active suicidality,
• acute psychosis,
• active substance use<6mo or
• pregnant or nursing females