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Supplementation of Vitamin D in those with low levels will increase the level and result in some improvement in health and psychopathology measures.
Subjects with levels of Vitamin D between 7ng/ml and 30ng/ml will, after signing consent forms, be randomly assigned to either start immediately on Vitamin D for three months or to start after a delay of three months. Those with levels below 7gn/ml will start immediately. All will be evaluated monthly with blood tests, PANSS, movement disorder ratings and information on health and progress from the clinical chart.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Immediate Vitamin D3 | Active Comparator | Will start Vitamin D3 immediately |
|
| Three month delay | Active Comparator | Half the subjects will be delayed three months (but evaluated) before getting Vitamin D3. (If the level is very low they will start immediately) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin D3 | Dietary Supplement | 50,000 units of Vitamin D3 weekly |
|
| Measure | Description | Time Frame |
|---|---|---|
| Psychopathology as measured by the PANSS | PANSS is being done every month | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| movement disorder | AIMS (for tardive dyskinesia), Simpson-Angus (for Parkinsonism) and Barnes (for Akathisia) movement disorder rating scales will be completed monthly. | three months |
| General Health |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| NIgel Bark, MD | Bronx Psychiatric Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bronx Psychiatric Center | The Bronx | New York | 10461 | United States |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D011618 | Psychotic Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| Vitamin D3 | Dietary Supplement | Vitamin D3 50,000 units weekly |
|
|
Measured by staff observation and reports, Labs for example glucose mg/dL, HgbA1c %A1c, Vitamin D ng/ml, calcium mg/dL, assessed monthly
| three months |
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |