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| Name | Class |
|---|---|
| National Science and Technology Council, Taiwan | OTHER_GOV |
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The main purpose of this study is to get the urethra and pelvic sonographic imaging by 4D ultrasound examinations, and to correlate the sonographic findings with urodynamic variables, pad weights and LUTS. Besides, the associations of the blood flow of vagina/urethra and sexual dysfunction can be explored.
Female lower urinary tract dysfunction includes stress urinary incontinence, overactive bladder syndrome and voiding dysfunction. There are a lot of bladder studies, such as researches of bladder wall thickness and bladder volume. However, there were few studies of urethra for female patients with lower urinary tract symptoms (LUTS), especially for storage disorder. Thus, the main purpose of this study is to get the urethra and pelvic sonographic imaging by 4D ultrasound examinations, and to correlate the sonographic findings with urodynamic variables, pad weights and LUTS. The investigators hope to identify important LUTS sonographic biomarkers that can be used by primary physicians as a tool for assess female LUTS, and thus decreasing the need of further invasive urodynamic studies.
Besides, the associations of the blood flow of vagina/urethra and sexual dysfunction (assessed by female sexual function index) can be explored.
In addition, women who receive antimuscarinics treatment will receive follow-up 4D imaging and request to complete questionnaire 12 weeks later.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adult women with lower urinary tract symptoms | Adult women (not less than 20 year-old) with lower urinary tract symptoms |
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| Measure | Description | Time Frame |
|---|---|---|
| Urethral/pelvic blood flow perfusion pattern between subgroups of women with lower urinary tracts | We will get the associations of urethral/pelvic blood flow perfusion pattern between subgroups of women with lower urinary tracts, and the above results will be compared to that of the asymptomatic control group. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Urethral/pelvic blood flow perfusion pattern after antimuscarinics | We will compare the urethral/pelvic blood flow perfusion pattern between the baseline and 12 weeks' antimuscarinic treatment (solifenacin 5 mg SR qd or tolerodine 4 mg ER qd) in women with overactive bladder syndrome. | 12 weeeks |
| Measure | Description | Time Frame |
|---|---|---|
| The subgroup differences of urethral/pelvic volume, hiatal area and rupture of puborectalis muscles | we will use 4 D ultrasound to assess the urethral/pelvic volume, hiatal area and rupture of puborectalis muscles among subgroups of women with lower urinary tract symptoms, and the above results will be compared to that of the control group. Besides, the correlation of imaging findings and clinical symptoms (such as lower urinary tract symptoms and sexual dysfunction) will be compared. |
Inclusion Criteria:
Exclusion Criteria:
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Women with lower urinary tract symptoms
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| Name | Affiliation | Role |
|---|---|---|
| Sheng-Mou Hsiao, MD | Department of Obstetrics & Gynecology, Far Eastern Memorial Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Far Eastern Memorial Hospital | New Taipei City | 220 | Taiwan |
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| 1 day |
| ID | Term |
|---|---|
| D059411 | Lower Urinary Tract Symptoms |
| D012735 | Sexual Dysfunction, Physiological |
| ID | Term |
|---|---|
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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