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| ID | Type | Description | Link |
|---|---|---|---|
| 551-2012 | Other Identifier | University of Florida |
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Study objectives:
Hypotheses:
Cardiovascular function will be measured at baseline in older healthy adults and young healthy controls. Older adults will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week exercise intervention, baseline measures will be repeated in the older adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High intensity aerobic interval training | Experimental | Older adults will complete 8 weeks of high intensity aerobic interval exercise training. |
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| Continuous moderate intensity exercise | Experimental | Older adults will complete 8 weeks of continuous moderate intensity exercise training. |
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| Non-exercise control group | No Intervention | Older adults assigned to the non-exercise control group will maintain their normal lifestyle for 8 weeks. | |
| Young Healthy controls | No Intervention | Young healthy subjects will be assigned to the healthy control group and will undergo baseline measures only. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intensity aerobic interval training | Other | Supervised aerobic interval training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in vascular endothelial function | Brachial flow-mediated dilation using ultrasonography | At baseline and after 8 weeks of exercise training |
| Measure | Description | Time Frame |
|---|---|---|
| Change in factors related with endothelial function | Blood and cellular markers of oxidative stress and inflammation | At baseline and after 8 weeks of exercise training |
| Change in arterial stiffness |
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Inclusion Criteria for older adults:
Inclusion Criteria for young adults:
Exclusion Criteria:
history of diabetes
history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
history of renal impairment
history of gout or hyperuricemia
history of hepatic disease or infection with hepatitis B, C
history of seizures, or other relevant on-going or recurrent illness
recent (within 3 months) or recurrent hospitalizations
use of tobacco products
>5 % weight change in the prior 6 months.
current intake of medications that may affect study results
participation in regular aerobic exercise training (>30 minutes,
premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
pregnancy (positive urine pregnancy test) or lactation
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| Name | Affiliation | Role |
|---|---|---|
| Demetra D Christou, Ph.D | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Florida | Gainesville | Florida | 32611 | United States |
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| Continuous moderate intensity exercise | Other | Supervised exercise training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 47 minutes and will consist of continuous moderate intensity cycling at 70% of HRmax. |
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Arterial stiffness and wave reflection will be measured using the SphygmoCor device
| At baseline and after 8 weeks of exercise training |
| Change in cardiac function | Left ventricular systolic and diastolic function will be measured using echocardiography | At baseline and after 8 weeks of exercise training |
| Change in maximal oxygen consumption | Maximal oxygen consumption will be measured using online computer-assisted open-circuit spirometry during incremental treadmill exercise | At baseline and after 8 weeks of exercise training |