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| ID | Type | Description | Link |
|---|---|---|---|
| 280-2012 | Other Identifier | Legacy study | |
| 1R21AG050203-01 | U.S. NIH Grant/Contract | View source | |
| OCR12584 | Other Identifier | University of Florida |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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The study objectives are:
The investigators hypothesize that compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in adults with type 2 diabetes.
Cardiovascular function will be measured at baseline in adults with type 2 diabetes and in age-matched healthy controls. Research volunteers with type 2 diabetes who meet the inclusion criteria will be randomized to the aerobic interval training group, continuous moderate exercise group or non-exercise control group. At the end of the 8-week randomized control exercise intervention, baseline measures will be repeated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High intensity aerobic interval training | Experimental | Type 2 diabetes subjects will complete 8 weeks of high intensity aerobic interval exercise training. |
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| Continuous moderate intensity exercise | Experimental | Type 2 diabetes subjects will complete 8 weeks of continuous moderate intensity exercise training. |
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| Non-exercise control group | No Intervention | Type 2 diabetes subjects assigned to the non-exercise control group will maintain their normal lifestyle for 8 weeks. | |
| Healthy control group | No Intervention | Healthy subjects will be assigned to the healthy control group and will undergo baseline measures only. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intensity aerobic interval training | Other | Supervised aerobic interval training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in vascular endothelial function | Brachial flow mediated dilation using ultrasonography | At baseline and after 8 weeks of exercise training |
| Measure | Description | Time Frame |
|---|---|---|
| Change in factors related with endothelial function | Blood and cellular markers of adiponectin, oxidative stress and inflammation. | At baseline and after 8 weeks of exercise training |
| Change in arterial stiffness |
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Inclusion Criteria for type 2 diabetes :
Inclusion criteria for healthy control group:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Demetra D Christou, Ph.D | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Florida | Gainesville | Florida | 32611 | United States |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Continuous moderate intensity exercise | Other | Supervised exercise training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 47 minutes and will consist of continuous moderate intensity cycling at 70% of HRmax. |
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Arterial stiffness (pulse wave velocity) and wave reflection (augmentation index) will be measured using the SphygmoCor device.
| At baseline and after 8 weeks of exercise training |
| Change in cardiac function | Left ventricular systolic and diastolic function will be measured using echocardiography. | At baseline and after 8 weeks of exercise training |
| Change in maximal oxygen consumption | Maximal oxygen consumption will be measured using online computer-assisted open-circuit spirometry during incremental treadmill exercise. | At baseline and after 8 weeks of exercise training |
| D004700 | Endocrine System Diseases |