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The investigators will assess the efficacy of parent delivered interventions in the treatment of social and communication deficits in children with autism. By collecting information about parent and child functioning before and after intervention, the investigators will be able to determine whether the intervention is effective in improving child social communication and reducing parent stress.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Developmentally Based Intervention | Experimental |
| |
| Behaviorally Based Intervention | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pivotal Response Training (PRT) | Behavioral | The behaviorally-based intervention is a treatment model that uses the principles of Applied Behavior Analysis (Koegel, Openden, Fredeen, & Koegel, 2006) to increase children's adaptive behaviors and decrease maladaptive behaviors. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in CGI-S (Clinical Global Impression - Severity) | Difference from Baseline to Week 12 | |
| Change in SRS (Social Responsiveness Scale) | Difference from Baseline to Week 12 | |
| Change in CDI (Communicative Development Survey) Score | Difference from Baseline to Week 12 | |
| Change in social and communication behaviors as assessed by standardized laboratory observations | Difference from Baseline to Week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in VABS (Vineland Adaptive Behavior Scale) Score | Difference from Baseline to Week 12 | |
| Change in social and communication behaviors as assessed from home videos | Difference from Baseline to Week 12 |
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Inclusion Criteria for autism participants:
Inclusion Criteria for developmentally delayed participants:
Exclusion Criteria for autism participants:
Exclusion Criteria for developmentally delayed subjects:
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| Name | Affiliation | Role |
|---|---|---|
| Antonio Y Hardan, M.D. | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University School of Medicine | Stanford | California | 94305 | United States |
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| ID | Term |
|---|---|
| D001321 | Autistic Disorder |
| D002658 | Developmental Disabilities |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| PACE Therapy | Behavioral | The developmentally based intervention is grounded in a development theory, that focuses on child-directed interactions with warm and caring individuals that aid in acquiring missed developmental and functional milestones. |
|
| PACE and PRT Hybrid | Behavioral | The hybrid based treatment has an eclectic approach that incorporates both systematic (behaviorally-based) and affect-based learning (developmentally-based)that focuses on increasing children's skill development (http://www.pacificautism.org). |
|
| Change in PSI (Parenting Stress Index) Score | Difference from Baseline to Week 12 |
| Change in FES (Family Empowerment Scale) Score | Difference from Baseline to Week 12 |
| Change in frequency and duration of investigation therapy | Difference from Baseline to Week 12 |
| Change in demographics data | Difference from Baseline to Week 12 |