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| Name | Class |
|---|---|
| Alliance for Potato Research and Education | OTHER |
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This study is designed to compare the effect of sources of potassium on uptake and the effect of potassium on blood pressure.
The study will compare uptake of potassium from three different doses and sources; supplements (720, 1440 and 2160 mg) potatoes (720, 1440 and 2160 mg) or French fries (2160 mg).
During 9 phases, participants will consume a controlled diet with the supplements, potato or french fries (every other week for 5 days). On the 4th day, blood and urine samples will be taken to monitor potassium uptake and excretion. Measures of blood pressure will be analyzed at defined time points throughout the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo control | Placebo Comparator | Subjects will consume tablets containing no potassium in addition to a basal diet containing 2336 mg potassium |
|
| Low dose potassium gluconate | Experimental | Subjects will consume 720 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium |
|
| Medium dose potassium gluconate | Experimental | Subjects will consume 1440 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium |
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| High dose potassium gluconate | Experimental | Subjects will consume 2160 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium |
|
| Low dose potato | Experimental | Subjects will consume 720 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo control | Dietary Supplement |
| ||
| Low dose potassium gluconate |
| Measure | Description | Time Frame |
|---|---|---|
| Bioavailability of Potassium | After 4 days of acclimation to the supplementation, absorption of potassium will be measured. | 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Pressure Response to Potassium | Differences in blood pressure will be measured between levels of potassium consumption. | 6 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Connie M Weaver, Ph.D. | Purdue University | Principal Investigator |
| Berdine R Martin, Ph.D. | Purdue University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Purdue University | West Lafayette | Indiana | 47907 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27413123 | Derived | Macdonald-Clarke CJ, Martin BR, McCabe LD, McCabe GP, Lachcik PJ, Wastney M, Weaver CM. Bioavailability of potassium from potatoes and potassium gluconate: a randomized dose response trial. Am J Clin Nutr. 2016 Aug;104(2):346-53. doi: 10.3945/ajcn.115.127225. Epub 2016 Jul 13. |
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| Medium dose potato | Experimental | Subjects will consume 1440 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium |
|
| High dose potato | Experimental | Subjects will consume 2160 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium |
|
| High dose French fries | Experimental | Subjects will consume 2160 mg potassium in the form of french fries daily in addition to a basal diet containing 2336 mg potassium |
|
| Basal diet control | Experimental | Subjects will consume a basal diet containing 2336 mg potassium daily |
|
| Dietary Supplement |
|
| Medium dose potassium gluconate | Dietary Supplement |
|
| High dose potassium gluconate | Dietary Supplement |
|
| Low dose potato | Dietary Supplement |
|
| Medium dose potato | Dietary Supplement |
|
| High dose potato | Dietary Supplement |
|
| High dose French fries | Dietary Supplement |
|
| Basal diet control | Dietary Supplement |
|