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This study compares the effects of isovolumetric (325 ml) preloads of chocolate milk supplemented with sodium alginates at incremental doses on inter-meal glucose levels, appetite scores and food intake in healthy adult men. The findings of this study will illustrate whether the addition of sodium alginate to chocolate milk will improve the glycemic properties of chocolate milk and will potentiate its satiating characteristics. This study will also elucidate whether sodium alginates, incorporated into chocolate milk, will influence glycemia, appetite sensations and food intake in a dose-dependent manner. It is hypothesized that there will be a synergy between milk and sodium alginate beyond either alone. When combined with milk components, sodium alginate is expected to improve glycemia and induce satiety more than does either milk alone or alginate alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sodium alginate-free chocolate milk | Experimental | Sodium alginate-free chocolate milk (1% fat) (Beatrice Ltd., Toronto, Ontario) |
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| 1.25% sodium alginate chocolate milk | Experimental | Chocolate milk (Beatrice Ltd., Toronto, Ontario) with 1.25% sodium alginate |
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| 2.5% sodium alginate chocolate milk | Experimental | Chocolate milk (Beatrice Ltd., Toronto, Ontario) with 2.5% sodium alginate |
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| 2.5% sodium alginate milk-free water-based solution | Experimental | Water solution with 2.5% sodium alginate |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary intervention | Other | All arms were given to all participants, in a randomized order, to be consumed within 10 min after 12-h overnight fasting. |
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| Measure | Description | Time Frame |
|---|---|---|
| Satiety Change | Pre-meal changes from 0 min; Post-meal changes from 120 min Satiety scores (mm) were assessed using 100-mm "Motivation to Eat" visual analog scale questionnaires. A composite score of the four appetite questions, including Desire to Eat, Hunger, Fullness and Prospective Food Consumption, in the "Motivation to Eat" visual analog scale was calculated to obtain the average appetite score for statistical analysis. | 0, 10, 20, 30, 45, 60, 75, 90 and 120 min (pre-meal) and 140, 170, 200, 230 and 260 min (post-meal) after consumption of the treatments |
| Measure | Description | Time Frame |
|---|---|---|
| Food Intake | Food intake (kCal) was assessed 120 min after consumption of the treatments, using an ad libitum pizza lunch meal. Participants were asked to eat, during a 20-min period, until feeling comfortably full. | 120 min |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Glucose Change | Pre-meal changes from 0 min; Post-meal changes from 120 min Blood glucose (mmol/L) was measured using finger prick capillary blood sample. | 0, 10, 20, 30, 45, 60, 75, 90 and 120 min (pre-meal) and 140, 170, 200, 230 and 260 min (post-meal) after consumption of the treatments |
| Serum Insulin Change |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| G. Harvey Anderson, PhD | University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutritional Sciences, FitzGerald Building | Toronto | Ontario | M5S 3E2 | Canada |
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| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| ID | Term |
|---|---|
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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Pre-meal changes from 0 min; Post-meal changes from 120 min Serum insulin (μU/mL) was measured using finger prick capillary blood sample. |
| 0, 30, 60, 120 (pre-meal), and 140, 170 and 200 min (post-meal) after consumption of treatments |