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There is evidence that intense physical activity has a potential effect on thrombotic events due to catecholamine release. The hormones leptin and adiponectin have been used as markers of cardiovascular risk, but they are few and contradictory studies that relate physical training intensity and duration of high plasma concentrations of these hormones. The use of antioxidants, such as proanthocyanidins present in grapes, may help in reducing the undesirable effects of intense training.
Fifty four Brazilian healthy military without hyperglycemia, diabetes mellitus and endocrine disease were enrolled in this study. All subjects were high physically military trained. The Ethical Committee of the Universidade do Estado do Rio de Janeiro in Brazil (COEP008/2011) approved the study protocol. Informed consent was obtained from each subject after explanation of purpose and risks of all procedures used.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dietary Supplement | Experimental | Before the exercise, the individuals intake only one capsule with 205 mg of the grape fruit extract in capsule with 205 mg. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| grape fruit (vitis vinifera) extract in capsule with 205 mg | Dietary Supplement | Before the exercise the indivuduals intake only one capsule of the grape fruit extract with 205 mg. This dosage is free of contraindications according to others studies. |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the changes of oxidative stress, microcirculation parameters, inflammation biomarkers and plasma adipokines in vitis vinifera extract supplemented and placebo subject before and after high intense training | This study will last 24 months (2013-2015) |
| Measure | Description | Time Frame |
|---|---|---|
| Differences between body composition and microcirculation parameters in vitis vinifera extract supplemented and placebo subject before and after high intense training | This study will last 24 months (2013-2015) | |
| Differences between oxidative stress biomarkers in vitis vinifera extract supplemented and placebo subject before and after high intense training |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| M C G, MD | Contact | 55 21 23340679 | 218 | marianagoncalves.mg@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| J C Koury, PhD | Instituto de Nutrição Universidade do Estado do Rio de Janeiro - Brazil | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidade do Estado do Rio de Janeiro | Recruiting | Rio de Janeiro | Rio de Janeiro | 20550900 | Brazil |
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| ID | Term |
|---|---|
| D001265 | Athletic Injuries |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| C000722782 | whole grape extract |
| D002214 | Capsules |
| ID | Term |
|---|---|
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |
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| This study will last 24 months (2013-2015) |
| Differences between inflammation biomarkers in vitis vinifera extract supplemented and placebo subject before and after high intense training | This study will last 24 months (2013-2015) |
| Differences between adipokines in vitis vinifera extract supplemented and placebo subject before and after high intense training | This study will last 24 months (2013-2015) |